Larazotide: The Simple Peptide That Could Transform Gut Health—and More
Larazotide: The Simple Peptide That Could Transform Gut Health—and More
Imagine a tiny peptide with the power to restore gut integrity, reduce inflammation, and even help combat viral infections. That’s exactly what Larazotide offers—a breakthrough in peptide therapy that Wisconsin Institute of Functional Medicine is proud to provide to patients looking for cutting-edge solutions to chronic gut issues.
What Is Larazotide?
Larazotide is a synthetic 8-amino-acid peptide originally developed for celiac disease. It works by blocking zonulin, a protein, responsible for regulating tight junctions in the gut lining. When zonulin levels are too high, the gut barrier becomes leaky, allowing harmful substances like bacteria, toxins, and undigested food particles to enter the bloodstream. This can lead to widespread inflammation, digestive issues, and even systemic health problems.
The Zonulin Connection: More Than Just Celiac Disease
Most people have never heard of zonulin, yet it plays a critical role in many conditions beyond celiac disease. Viral infections, bacterial imbalances, toxins, and inflammatory triggers can all increase zonulin levels, compromising gut integrity. When this happens, the body becomes more vulnerable to chronic inflammation, autoimmune reactions, and even neurological conditions.
But here’s where it gets even more interesting: Zonulin receptors aren’t just in the gut—they’re everywhere. From the lungs to the brain, when tight junctions weaken, the entire body feels the effects. This is why gut health is directly linked to immune health, neurological function, and overall well-being.
How Larazotide Works
By blocking zonulin, Larazotide keeps tight junctions intact, reducing the inflammatory cascade that results from a weakened gut barrier. The best part? It works locally in the gut—meaning it doesn’t need to be absorbed into the bloodstream to have a powerful effect. At 500 mcg taken twice daily (BID), it has been shown to safely improve gut barrier function without significant side effects.
Why This Matters for More Than Just Digestion
A leaky gut doesn’t just cause bloating or food sensitivities—it can lead to widespread immune dysfunction. Researchers have found that increased intestinal permeability contributes to:
- Autoimmune diseases
- Chronic fatigue
- Neurological conditions (such as brain fog and migraines)
- Increased susceptibility to viral infections, including COVID-19
In fact, some studies suggest that high zonulin levels allow viruses like COVID-19 to bypass the body’s natural defenses, worsening symptoms and prolonging recovery. By reinforcing the gut barrier, Larazotide may help reduce viral inflammation and limit the spread of harmful toxins and pathogens throughout the body.
Is Larazotide Safe?
Absolutely. Clinical trials have demonstrated no serious adverse effects, even at doses significantly higher than what is typically prescribed. In nearly 500 patients studied, Larazotide was well-tolerated and showed no major safety concerns. This makes it an attractive option for individuals looking for natural, non-absorbed therapy to improve their gut health.
The Future of Gut Health Starts Here
At Wisconsin Institute of Functional Medicine, we believe in using scientifically-backed peptide therapies to enhance patient outcomes. Larazotide offers an exciting new avenue for those struggling with poor gut health, inflammation, and beyond.
If you’ve been battling digestive issues, autoimmune symptoms, or unexplained fatigue, it may be time to explore how Larazotide can help you restore balance from the inside out.
Interested in learning more? Contact us today to see if Larazotide therapy is right for you. https://wisconsinfunctionalmed.com/contact/
